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Indeed, the cell proliferation is the most important characteristic of the tumor cells and could be indicated by the cell viability. A structural modification of stem mucilage polysaccharide by deacetylation of 2- O-glucomannan was investigated whether it would affect its stimulatory effect on cytokine production. Pregnancy and Breast-feeding: There isn't enough information to know if dendrobium is safe to take during pregnancy or breast-feeding.

In light of their traditional importance as medicinal plants, knowledge on the constituents of various Dendrobium species and their pharmacological activities has been growing, and methodologies have been developed for the effective propagation of members of this genus or for the authentication of Dendrobium drugs from its adulterants [ 3, 4]. The cluster of differentiation (CD) gene family and toll-like receptor-9 protein (TLR9) were affected by the treatment of Dendrobium mixtures. They also increased NK cell cytotoxicity; it was observed that the optimal polysaccharide concentration was 50 μg/mL, which demonstrates that a high concentration is not essential for strong stimulating effects.w., an effective T/C value of 172% with a significant increase in life span compared to control was obtained. In a more recent study, it has been demonstrated that the reduction of migration and invasion of H292 cells by TDB was reduced by decreasing migration-regulating proteins, including integrins αv, α4, β1, β3 and β5, as well as activated focal adhesion kinase (pFAK), activated Ras-related C3 botulinum toxin substrate 1 (Rac1-GTP) and cell division control protein 42 (Cdc42) [ 29]. It was clearly demonstrated, that DNLA treatment (40, 80, 160 mg/kg/d for 7 days) significantly protected the rat brain from LPS-induced (50 µg) neuroinflammation and cognitive dysfunction.

When taken by mouth: There isn't enough information to know if dendrobium is safe or what the side effects might be when taken by mouth. Moscatilin also inhibits growth and induces apoptosis and mitotic catastrophe in human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) derived cell lines [ 36]. Moreover, at this dose, DNP4-2 strongly promoted the secretion of cytokines TNF-α, IFN-γ and IL-2 [ 102]. Overexpression of CD proteins in diabetic patients provides a fertile environment for tumor growth and differentiation. candidum at any concentration and any time point caused no inhibitory effect on cell proliferation of MCF10A cell line, suggesting its selectivity against MCF-7 breast cancer cell proliferation.Pre-treatment with DP was further demonstrated to be protective in a dose-dependent manner in response to the TNF-α stimulus. Polysaccharides are the main effective ingredients of Dendrobium species with the strongest immunomodulatory activities ( Table 4). Moreover, splenocyte proliferation was substantially enhanced by LPS stimulation in a dose-dependent manner in both DTP-treated groups (100 and 300 mg/kg) and the same DTP treatments significantly up regulated the proliferation of splenocytes through ConA stimulation, compared with the control group.